Executive function, pragmatic language and CBCL psychopathological profiles in children with neurodevelopmental disorders and family history of schizophrenia
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https://doi.org/10.31766/revpsij.v37n1a2Keywords:
neurodevelopmental disorders, schizophrenia spectrum and other psychotic disorders, endophenotypes, executive function, social communication disorderAbstract
Introduction: The CBCL is a standardized form that parents fill out to describe their children´s behavioral and emotional problems. Previous studies have suggested that two subscales, “withdrawal-depressed” and mainly “thought problems” may have utility as a psychosis risk screening measure in youth. Executive function and higher-order language dysfunctions have been postulated as potential endophenotypes for schizophrenia.
Objectives: To identify by means of the two CBCL subscales mentioned above, a group of children and adolescents with higher ratings amongst those patients attending an outpatient psychiatric clinic, who present a neurodevelopmental disorder and a family history of schizophrenia
Material and methods: Parents filled out CBCL, CCC-Childrens Communication Checklist- (evaluates pragmatic language) and BRIEF-2 (Behavior Rating Inventory of Executive Function).
Results: Twenty-one children were included (16 males; 5 females). Mean age 11,4 y/o. Main diagnoses were ADHD (66,7%), Learning Disorder (9,5%) and ASD (9,5%). CBCL subscales “withdrawndepressed” and “thought problems” discriminated two groups. One with higher ratings (above Pc70) showing the presence of symptoms (n=11) and the other with lower ratings (below Pc70) indicating symptom absence (n=10). The first group showed more pragmatic language difficulties as well as poorer executive function.
Conclusions: A more comprehensive dimensional evaluation of the psychopathology of children with neurodevelopmental disorders and family history of schizophrenia, by means of CBCL, may provide a better description of premorbid difficulties, helping to identify more vulnerable cases for long term follow up and early intervention.
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