A case report of 1q21.1 microdeletion and psychosis

Abstract

The 1q21.1 microdeletion does not cause a typical clinical syndrome, since some people with the deletion do not show clinical findings and others have different manifestations. However, alterations related to the absence of localized genes in that fragment have been described. These characteristics include microcephaly, dysmorphic facial features, ocular alterations, heart diseases, genitourinary anomalies, skeletal malformations, seizures, neurodevelopmental disorders, learning disabilities and mild intellectual disability. About psychiatric pathologies, there is a higher incidence of autism spectrum disorders, attention deficit hyperactivity disorder, anxiety and mood disorders, sleep disorders and schizophrenia.

We report a clinical case of a female patient with the 1q21.1 microdeletion admitted in a Child and Adolescent Psychiatry Unit with delusional symptoms and hallucinations.