Programación fetal metabólica en la salud mental

Descargas

Publicado

2019-12-27

Cómo citar

García-Rizo, C. . (2019). Programación fetal metabólica en la salud mental. Revista De Psiquiatría Infanto-Juvenil, 36(4), 3–5. https://doi.org/10.31766/revpsij.v36n4a1

Autores/as

DOI:

https://doi.org/10.31766/revpsij.v36n4a1

Palabras clave:

Programación fetal metabólica, Barker, epigenética, trastornos mentales severos

Resumen

El concepto de programación fetal metabólica, entendido como toda una serie de modificaciones epigenéticas que sufre el feto durante su periodo intrauterino en respuesta a los estímulos recibidos de la madre orientado a asegurar su supervivencia (1), tiene una importancia añadida en la salud mental infanto-juvenil. Actualmente se considera que los trastornos mentales severos (TMS), esquizofrenia, trastorno bipolar y trastorno depresivo mayor entre otros, tiene su origen en una combinación gen-ambiente, siendo las complicaciones obstétricas un factor ambiental bien replicado en diferentes estudios (2). La presencia de complicaciones obstétricas en estos pacientes se ha asociado a una edad de inicio más precoz del TMS (3), por ende, una mayor incidencia en la etapa infanto-juvenil.

Descargas

Los datos de descargas todavía no están disponibles.

Citas

Gluckman PD, Hanson MA. Developmental origins of Health and Disease. New York: Cambridge University Press; 2006. DOI: https://doi.org/10.1017/CBO9780511544699

Pugliese V, Bruni A, Carbone EA, Calabrò G, Cerminara G, Sampogna G, et al. Maternal stress, prenatal medical illnesses and obstetric complications: Risk factors for schizophrenia spectrum disorder, bipolar disorder and major depressive disorder. Psychiatry Res. 2019; 271: 23–30. https://doi.org/10.1016/j.psychres.2018.11.023 DOI: https://doi.org/10.1016/j.psychres.2018.11.023

Buoli M, Bertino V, Caldiroli A, Dobrea C, Serati M, Ciappolino V, et al. Are obstetrical complications really involved in the etiology and course of schizophrenia and mood disorders? Psychiatry Research. 2016; 241:297–301. https://doi.org/10.1016/j.psychres.2016.05.014 DOI: https://doi.org/10.1016/j.psychres.2016.05.014

Hales CN, Barker DJ. Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis. Diabetologia. 1992;35(7):595–601. DOI: https://doi.org/10.1007/BF00400248

http://www.ncbi.nlm.nih.gov/pubmed/1644236

McIntyre RS, Mancini DA, Pearce MM, Silverstone P, Chue P, Misener VL, et al. Mood and Psychotic Disorders and Type 2 Diabetes: A Metabolic Triad. Can J Diabetes. 2005;29(2):122–32.

Garcia-Rizo C, Kirkpatrick B, Fernandez-Egea E, Oliveira C, Bernardo M. Abnormal glycemic homeostasis at the onset of serious mental illnesses: A common pathway. Psychoneuroendocrinology. 2016; 67:70–75. https://doi.org/10.1016/j.psyneuen.2016.02.001 DOI: https://doi.org/10.1016/j.psyneuen.2016.02.001

Greenhalgh AM, Gonzalez-Blanco L, Garcia-Rizo C, Fernandez-Egea E, Miller B, Arroyo MB, et al. Meta-analysis of glucose tolerance, insulin, and insulin resistance in antipsychotic-naïve patients with nonaffective psychosis. Schizophr Res. 2017;179:57–63. http://dx.doi.org/10.1016/j.schres.2016.09.026 DOI: https://doi.org/10.1016/j.schres.2016.09.026

Nordentoft M, Wahlbeck K, Hällgren J, Westman J, Ösby U, Alinaghizadeh H, et al. Excess Mortality, Causes of Death and Life Expectancy in 270,770 Patients with Recent Onset of Mental Disorders in Denmark, Finland and Sweden. Burne T, editor. PLoS One. 2013 Jan 25;8(1):e55176. http://www.ncbi.nlm.nih.gov/pubmed/23372832 DOI: https://doi.org/10.1371/journal.pone.0055176

Garcia-Rizo C, Fernandez-Egea E, Bernardo M, Kirkpatrick B. The thrifty psychiatric phenotype. Acta Psychiatr Scand. 2015 Jan;131(1):18–20. http://www.ncbi.nlm.nih.gov/pubmed/25041130 DOI: https://doi.org/10.1111/acps.12309

Garriga M, Wium-Andersen MK, Wium-Andersen IK, Nordentoft M, Osler M. Birth dimensions, severe mental illness and risk of type 2 diabetes in a cohort of Danish men born in 1953. Eur Psychiatry. 2019 Oct 7;62:1–9. http://www.ncbi.nlm.nih.gov/pubmed/31505317 DOI: https://doi.org/10.1016/j.eurpsy.2019.08.015

Garcia-Rizo C, Bioque M, Mezquida G, Amoretti S, Cuesta M, Díaz-Caneja CM, et al. Birth weight and antipsychotic induced weight gain: A prenatal programming approach in the PEPs study. Schizophr Res, Press. 2020; DOI: https://doi.org/10.1016/j.schres.2019.12.030

Garriga M, Fernandez-Egea E, Mallorqui A, Serrano L, Oliveira C, Parellada E, et al. Antipsychotic-induced weight gain and birth weight in psychosis: A fetal programming model. J Psychiatr Res. 2019 May 4; 115:29–35. https://doi.org/10.1016/j.jpsychires.2019.05.004 DOI: https://doi.org/10.1016/j.jpsychires.2019.05.004

Ziauddeen H, Garcia-Rizo C, Bernardo M, Kirkpatrick B, Ozanne SE, Jones PB, et al. Association of birth weight and the development of antipsychotic induced adiposity in individuals with treatment resistant schizophrenia. Eur Neuropsychopharmacol. 2016 Jun;26(6):972–8. http://linkinghub.elsevier.com/retrieve/pii/S0924977X16300062 DOI: https://doi.org/10.1016/j.euroneuro.2016.03.008

Insel TR. Rethinking schizophrenia. Nature. 2010 Nov 11;468(7321):187–93. http://www.ncbi.nlm.nih.gov/pubmed/21068826 DOI: https://doi.org/10.1038/nature09552

Costas A, Garcia-Rizo C, Bitanihirwe BKY, Penades R. Obstetric complications and brain imaging in schizophrenia: a systematic review. Undere Rev Psychol Med. 2019;

Freedman D, Bao Y, Kremen WS, Vinogradov S, McKeague IW, Brown AS. Birth weight and neurocognition in schizophrenia spectrum disorders. Schizophr Bull. 2013 May 1; 39(3):592–600. http://www.ncbi.nlm.nih.gov/pubmed/22378899 DOI: https://doi.org/10.1093/schbul/sbs008

Mezquida G, Fernandez-Egea E, Treen D, Mané A, Bergé D, Savulich G, et al. Difficulties in delivery and depressive symptomatology in schizophrenia. Rev Esp Psi Salud Ment. Press. 2020; DOI: https://doi.org/10.1016/j.euroneuro.2019.09.741

Ellman LM, Murphy SK, Maxwell SD, Calvo EM, Cooper T, Schaefer CA, et al. Maternal cortisol during pregnancy and offspring schizophrenia: Influence of fetal sex and timing of exposure. Schizophr Res. 2019; 213:15–22. https://doi.org/10.1016/j.schres.2019.07.002 DOI: https://doi.org/10.1016/j.schres.2019.07.002

Mezquida G, Fernandez-Egea E, Treen D, Mane A, Berge D, Savulich G, et al. Obstetric Phenotypes in the Heterogeneity of Schizophrenia. J Nerv Ment Dis. 2018; 206(11): 882–886. https://doi.org/10.1097/NMD.0000000000000897 DOI: https://doi.org/10.1097/NMD.0000000000000897

Garcia-Rizo C, Bitanihirwe BKY. Implications of Early Life Stress on Fetal Metabolic Programming of Schizophrenia: A Focus on Epiphenomena underlying Morbidity and Early Mortality. Under Rev Prog Neuro-Psychopharmacology Biol Psychiatry. Press. 2020; DOI: https://doi.org/10.1016/j.pnpbp.2020.109910