Clinical case report: depressive symptoms in an adolescent with Klinefelter syndrome

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Published

2013-03-12

How to Cite

Pérez Fominaya, M., Soriano Guillén, L., Muñoz Lorenzo, L., & Carballo Belloso, J. (2013). Clinical case report: depressive symptoms in an adolescent with Klinefelter syndrome. Revista De Psiquiatría Infanto-Juvenil, 30(1), 72–76. Retrieved from https://aepnya.eu/index.php/revistaaepnya/article/view/268

Issue

Vol. 30 No. 1 (2013)

Section

Case reports

Authors

  • M. Pérez Fominaya Hospital Universitario Fundación Jiménez Díaz
  • L. Soriano Guillén Hospital Universitario Fundación Jiménez Díaz
  • L. Muñoz Lorenzo Hospital Universitario Fundación Jiménez Díaz
  • J.J Carballo Belloso Hospital Universitario Fundación Jiménez Díaz

Keywords:

Klinefelter, testosterone, depression, chronic disease, adaptive reaction

Abstract

Klinefelter syndrome (47, XXY) is the most common sex chromosome aneuploidy in males. Principal effects include metabolic and endocrine disorders related to testosterone deficiency. Although not all males develop the characteristic symptoms of Klinefelter syndrome, testosterone deficiency is present in all of them. An increased incidence of anxiety and depression is reported in boys and adolescents with 47, XXY. Depressive symptoms have been associated to testosterone deficiency and also as an adaptive reaction to disease. Psychiatric treatment of depression in patients with Klinefelter syndrome has been limited to drug therapy and supportive psychotherapy. However, studies suggest that testosterone replacement may have an antidepressant effect in depressed adults with testosterone deficiency. The purpose of this case study is to report the course of depressive symptoms in an adolescent subject with Klinefelter syndrome treated with testosterone and psychotherapy.

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Author Biography

M. Pérez Fominaya, Hospital Universitario Fundación Jiménez Díaz

Correspondencia:
Margarita Pérez Fominaya.
C/ Martínez Izquierdo 16, escalera B 2ºD Madrid, 28028
Email: dra.fominaya@gmail.com
Teléfono de contacto: +0034618130495

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