High-risk mental states. Genetic vulnerability and childhood trauma. A case report
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Psychosis, children, adolescents, prodromes, traumaAbstract
Traumatic events in childhood have been associated with an increased risk of psychiatric disorders and given its high prevalence, it is likely to be a determinant of mental illness. Psychosis is an experience that reflects a dimensional psychopathological syndromic nature of affective components, cognitive style of thinking, loss of ego boundaries or a serious deterioration in the assessment of reality. We present the case of a teenager with a family genetic charge of severe mental disorder, who contacted the mental health service after attenuated psychotic symptoms and Brief and Limited Intermitent Psychosis, in the context of traumatic life events. A recent meta-analysis discusses the relationship between the risk of psychosis and early psychological trauma. It is suggested that psychological trauma may promote neurochemical changes and psychopathological of a vulnerable individual. It remains to study the role of psychotherapeutic interventions in the course of highrisk mental states and their possible evolution to a psychotic disorder.
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2. Birchwood M, Todd P, Jackson C. Early intervention in psychosis. The critical period hypothesis. Br J Psychiatry Suppl 1998; 172: 53-9.
3. McGorry PD, Yung AR, Phillips LJ, Yuen HP, Francey S, Cosgrave EM, et al. Randomized controlled trial of interventions designed to reduce the risk of progression to first-episode psychosis in a clinical sample with subthreshold symptoms. Arch Gen Psychiatry 2002; 59: 921-8.
4. Yung AR, McGorry PD. The prodromal phase of first-episode psychosis: past and current conceptualizations. Schizophr Bull 1996; 22: 353-70.
5. McLaughlin KA, Green JG, Gruber MJ, Sampson NA, Zaslavsky AM, Kessler RC. Childhood adversities and adult psychiatric disorders in the national comorbidity survey replication II: associations with persistence of DSM-IV disorders. Arch Gen Psychiatry 2010; 67: 124-32.
6. Bendall S, Jackson HJ, Hulbert CA, McGorry PD. Childhood trauma and psychotic disorders: a systematic, critical review of the evidence. Schizophr Bull 2008; 34: 568-79.
7. Heins M, Simons C, Lataster T, Pfeifer S, Versmissen D, Lardinois M, et al. Childhood trauma and psychosis: a case-control and case-sibling comparison across different levels of genetic liability, psychopathology, and type of trauma. Am J Psychiatry 2011; 168: 1286-94.
8. Read J, Bentall RP, Fosse R. Time to abandon the bio-bio-bio model of psychosis: Exploring the epigenetic and psychological mechanisms by which adverse life events lead to psychotic symptoms. Epidemiol Psichiatr Soc 2009; 18: 299-310.
9. Varese F, Smeets F, Drukker M, Lieverse R, Lataster T, Viechtbauer W, et al. Childhood Adversities Increase the Risk of Psychosis: A Meta- analysis of Patient-Control, Prospective- and Cross-sectional Cohort Studies. Schizophr Bull 2012; 38: 661-671.
10. Kandel ER. Biology and the future of psychoanalysis: a new intellectual framework for psychiatry revisited. Am J Psychiatry 1999; 156: 505-24.