Wolfram syndrome and psychiatric disorders: a case report
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Published
2014-12-17
How to Cite
Ferreira Frías, M., Geijo Uribe, M., Ímaz Roncero, C., Sotelo Martín, E., & Vásquez Cornieles, E. (2014). Wolfram syndrome and psychiatric disorders: a case report. Revista De Psiquiatría Infanto-Juvenil, 31(4), 47–51. Retrieved from https://aepnya.eu/index.php/revistaaepnya/article/view/136
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Section
Case reports
Keywords:
Wolfram Syndrome, Comorbidity, Anorexia NervosaAbstract
We report the case of a teenage 15 year old male with Wolfram syndrome, which is a less prevalent neurodegenerative condition characterized by the presence of diabetes mellitus and progressive bilateral optic atrophy. The patient was hospitalized in the child and adolescent psychiatry unit presenting restrictive anorexia nervosa that is a disease that until now, had never been associated with this syndrome. However, The Wolfram Syndrome has been related to a greater risk of suicide and depressive psychopathology.
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References
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2. Pena Outeiriño JM, Torrubia Romero FJ, Leal López A, Villodres Duarte A, Cruz Navarro N, Espinosa Olmedo FJ. Alteraciones urológicas en el DIDMOAD. Urodinámica aplicada 1990; 2: 138-42.
3. Nickl-Jockschat T1, Kunert HJ, Herpertz-Dahlmann B, Grözinger M. Psychiatric symptoms in a patient with Wolfram syndrome caused by a combination of thalamic deficit and endocrinological pathologies. Neurocase. 2008; 15 (1): 47-52.
4. Sequeira A1, Kim C, Seguin M, Lesage A, Chawky N, Desautels A, Tousignant M, Vanier C, Lipp O, Benkelfat C, Rouleau G, Turecki G. Wolfram syndrome and suicide: Evidence for a role of WFS1 in suicidal and impulsive behavior. Am J Med Genet B Neuropsychiatr Genet. 2003; 119B (1): 108-13.
5. Mauro Porcu, Ricardo Franzin. Wolfram’s Syndrome: case report. Rev Med Res 2010; 12 (2): 100-102.
6. Cryns K1, Sivakumaran TA, Van den Ouweland JM, Pennings RJ, Cremers CW, Flothmann K, Young TL, Smith RJ, Lesperance MM, Van Camp G. Mutational spectrum of the WFS1 gene in Wolfram syndrome, nonsyndromic hearing impairment, diabetes mellitus, and psychiatric disease. Hum Mutat. 2003; 22 (4): 275-87.
7. Swift M1, Swift RG. Wolframin mutations and hospitalization for psychiatric illness. Mol Psychiatry. 2005; 10 (8): 799-803.
8. Aluclu MU1, Bahceci M, Tuzcu A, Arikan S, Gokalp D. A new mutation in WFS1 gene (C.1522-1523delTA, Y508fsX421) may be responsible for early appearance of clinical features of Wolfram syndrome and suicidal behaviour. Neuro Endocrinol Lett. 2006; 27 (6): 691-4.
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