Very early / early Onset Schizophrenia and drug response: a complex binomial
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EOS, VEOS, Refractory/Refractoriness, clozapineAbstract
Early onset schizophrenia (EOS-under 15 years-) and very early onset schizophrenia (VEOS-under 13 years-) is a rare condition (12-33% and 1% of all cases respectively) which continues with adult schizophrenia, but has a worse prognosis due to associating more varied symptoms and a poorer response to psychopharmacological treatment (first-line drugs fail in 50% of patients, considering at this age, too, clozapine as third line treatment in refractory cases)
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