Postural Orthostatic Tachycardia Syndrome and Austism Spectrum Disorder
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Copyright (c) 2025 Revista de Psiquiatría Infanto-Juvenil
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https://doi.org/10.31766/revpsij.v42n2a6Keywords:
POTS syndrome, autonomic nervous system dysfunction, autism spectrum disorderAbstract
Introduction: Studies on the function of the autonomic nervous system in patients with autism spectrum disorder show a higher prevalence of autonomic nervous system dysfunction with greater sympathetic excitation. Among the different forms of autonomic nervous system dysautonomia, we find postural orthostatic tachycardia syndrome. Case description: We present the case of an adolescent diagnosed with autism spectrum disorder who, during a hospital admission, presented tachycardia, sweating, bluish discoloration of the extremities and marked asthenia. Assessed by the Cardiology Unit during admission, treatment with bisoprolol was initiated and aripiprazole was withdrawn. The symptoms, although intermittent, persisted over time, and the patient was referred to an arrhythmia unit. A tilt table test was performed, and the patient was diagnosed with postural orthostatic tachycardia syndrome. Conclusions and Discusion: Patients with autism spectrum disorder have a higher prevalence of autonomic nervous system dysfunction.
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Gibbons CH. Basics of autonomic nervous system function. Handb Clin Neurol. 2019; 160:407-18. https://doi.org/10.1016/B978-0-444-64032-1.00027-8 DOI: https://doi.org/10.1016/B978-0-444-64032-1.00027-8
Waxenbaum JA, Reddy V, Varacallo M. Anatomy, Autonomic Nervous System. Treasure Island (FL): StatPearls Publishing; 2023. https://www.ncbi.nlm.nih.gov/books/NBK539845/
Navarro X. Fisiología del sistema nervioso autónomo. Rev Neurol. 2002;35(6): 553-62. https://shorturl.at/HnKE5 DOI: https://doi.org/10.33588/rn.3506.2002013
Wehrwein EA, Orer HS, Barman SM. Overview of the Anatomy, Physiology, and Pharmacology of the Autonomic Nervous System. Compr Physiol. 2016;6(3):1239-78. https://doi.org/10.1002/cphy.c150037. DOI: https://doi.org/10.1002/j.2040-4603.2016.tb00714.x
Porges, S. W., Macellaio, M., Stanfill, S. D., McCue, K., Lewis, G. F., Harden, E. R, et al. Respiratory sinus arrhythmia and auditory processing in autism: modifiable deficits of an integrated social engagement system? Int J Psychophysiol. 2013;88(3): 261-70. https://doi.org/10.1016/j.ijpsycho.2012.11.009 DOI: https://doi.org/10.1016/j.ijpsycho.2012.11.009
Owens AP, Mathias CJ, Iodice V. Autonomic Dysfunction in Autism Spectrum Disorder. Front Integr Neurosci. 2021;15: 787037. https://doi.org/10.3389/fnint.2021.787037. DOI: https://doi.org/10.3389/fnint.2021.787037
Mulkey SB, du Plessis AJ. Autonomic nervous system development and its impact on neuropsychiatric outcome. Pediatr Res. 2019; 85(2): 120-6. https://doi.org/10.1038/s41390-018-0155-0. DOI: https://doi.org/10.1038/s41390-018-0155-0
Schondorf R, Low PA. Idiopathic postural orthostatic tachycardia syndrome: an attenuated form of acute pandysautonomia? Neurology. 1993;43(1):132-7. https://doi.org/10.1212/wnl.43.1_part_1.132 DOI: https://doi.org/10.1212/WNL.43.1_Part_1.132
Raj SR, Fedorowski A, Sheldon RS. Diagnosis and management of postural orthostatic tachycardia syndrome. CMAJ. 2022;194(10): E378-E385. https://doi.org/10.1503/cmaj.211373. DOI: https://doi.org/10.1503/cmaj.211373
Baker JR et al. Reduced Stroke Volume and Brain Perfusion Drive Postural Hyperventilation in Postural Orthostatic Tachycardia Syndrome. JACC Basic Transl Sci. 2024;9(8): 939-53. ISSN 2452-302X. https://doi.org/10.1016/j.jacbts.2024.04.011 DOI: https://doi.org/10.1016/j.jacbts.2024.04.011
Makris G, Agorastos A, Chrousos GP, Pervanidou P. Stress System Activation in Children and Adolescents With Autism Spectrum Disorder. Front Neurosci. 2022;15: 756628. https://doi.org/10.3389/fnins.2021.756628. DOI: https://doi.org/10.3389/fnins.2021.756628
Vernino S, Bourne KM, Stiles LE, Grubb BP, Fedorowski A, Stewart JM, et al. Postural orthostatic tachycardia syndrome (POTS): State of the science and clinical care from a 2019 National Institutes of Health Expert Consensus Meeting - Part 1. Auton Neurosci. 2021;235: 102828. https://doi.org/10.1016/j.autneu.2021.102828. DOI: https://doi.org/10.1016/j.autneu.2021.102828
Kakavand B, Centner A, Centner S, et al. The Prevalence of Anxiety and Depression in Children with Postural Orthostatic Tachycardia Syndrome (POTS): A Retrospective Study. Cureus. 2024;16(9): e69941. https://doi.org/10.7759/cureus.69941 DOI: https://doi.org/10.7759/cureus.69941
Boris, JR, Postural orthostatic tachycardia syndrome in children and adolescents. Auton Neurosci. 2018;15: 97-101. https://doi.org/10.1016/j.autneu.2018.05.004 DOI: https://doi.org/10.1016/j.autneu.2018.05.004
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