Programación fetal metabólica en la salud mental
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https://doi.org/10.31766/revpsij.v36n4a1Palabras clave:
Programación fetal metabólica, Barker, epigenética, trastornos mentales severosResumen
El concepto de programación fetal metabólica, entendido como toda una serie de modificaciones epigenéticas que sufre el feto durante su periodo intrauterino en respuesta a los estímulos recibidos de la madre orientado a asegurar su supervivencia (1), tiene una importancia añadida en la salud mental infanto-juvenil. Actualmente se considera que los trastornos mentales severos (TMS), esquizofrenia, trastorno bipolar y trastorno depresivo mayor entre otros, tiene su origen en una combinación gen-ambiente, siendo las complicaciones obstétricas un factor ambiental bien replicado en diferentes estudios (2). La presencia de complicaciones obstétricas en estos pacientes se ha asociado a una edad de inicio más precoz del TMS (3), por ende, una mayor incidencia en la etapa infanto-juvenil.
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