Treatment with atypical antipsychotics of Gilles de la Tourette syndrome
Downloads
Published
2005-03-01
How to Cite
Alcaina-Pròsper, T., López-Penalba, S., Martínez-Rey, T., & Añó-Torres, M. M. (2005). Treatment with atypical antipsychotics of Gilles de la Tourette syndrome. Revista De Psiquiatría Infanto-Juvenil, 22(1), 27–33. Retrieved from https://aepnya.eu/index.php/revistaaepnya/article/view/62
Issue
Section
Orginial article
Keywords:
Tourette, atypical, antipsychotics, child, adolescentAbstract
The optimal treatment of Gilles de la Tourette syndrome (GTS) involves educational and supportive interventions, psychological approaches and pharmacological treatment. Pharmacotherapy, especially with antipsychotic drugs, has been the most effective treatment modality in suppressing severe tics. Current treatment with atypical antipsychotics (risperidone, olanzapine) of children and adolescents with GTS appears to be as effective as traditional antipsychotics, while having fewer side effects. Comorbid conditions as attention-deficit/hyperactivity disorder, obsessive-compulsive disorder (OCD), and learning disorders, can be a source of more distress and impairment than the tics themselves. Drug treatment of OCD includes selective serotonin reuptake inhibitors (SSRIs) as sertraline. Objective: The purpose of this study was to assess the efficacy and safety of atypical antipsychotics in the treatment of GTS in children and adolescents. Method: This case study included four subjects (all boys) with a mean age of 11.00 +- 0.50 years.
All subjects met International Classification of Diseases (ICD-10) criteria for GTS. Three children also had a
comorbid OCD. Results: Clinical response, as measured by the Clinical Global Impression (CGI) scale showed
improvement and reduction in the severity of motor and phonic tics. The most common side effect was weight gain. Conclusions: These findings suggest that atypical antipsychotics appear to be effective and safe in diminishing motor and phonic tics frequency and intensity in children and adolescents with GTS.
Downloads
Download data is not yet available.
References
1. Apter A, pauls DL, Bleich A, Zohar A, Kron S, Ratzoni G, Dycian A, Kotler M, Weitzman A, Gadot N, Cohen DJ. An epidemiological study of Gilles de la Tourette’s syndrome in Israel. Arch Gen Psychiatry 1993; 50:734-738.
2. Azrin NH, Peterson AL. Habit reversal for the treatment of Tpourette syndrome. Behaviour Research and Therapy 1988; 11:347-355.
3. Azrin NH, Peterson AL. Treatment of Tourette syndrome by habit reversal: a waiting-list control group comparison. Behaviour Therapy 1990’; 21:305-318.
4. Bengi Semerci Z. Olanzapine in Tourette’s disorder. J Am Acad Child Adolesc Psychiat 2000; 39:140.
5. Bronheim S. An educator’s guide to Tourette syndrome. Journal of Learning Disabilities 1991; 24:17-22.
6. Bruggeman R, van der Linden C, Buitelaar JK, et al. Risperidone versus pimozide in Tourette’s disorder: a comparative double-blind parallelgroup study.J Clin Psychiatry 2001;50:912-924.
7. Bruun RD, Budman CL. Risperidone as a treatment for Tourette’s syndrome. J Clin Psychiatry 1996;57:29-31.
8. Bruun RD. Subtle and under recognized side effects of neuroleptic treatment in children with Tourette’s disorder. American Journal of Psychiatry 1988; 145:621-624.
9. Bruun RD. The natural history of Tourette’s syndrome. En: Cohen DJ, Bruun RD, Leckman JF, editors. Tourette’s syndrome and tic disorders: clinical understanding and treatment. New York: Wiley; 1988. págs. 21-39.
10. Burd L, Kerbeshian L, Wikenheiser M, Fisher W. A prevalence study of Gilles de la Tourette syndrome in North Dakota school-age children. J Am Acad Child Adolesc Psychiat 1986; 25:552-553.
11. Caine ED, McBride MC, Chiverton P, Bamford KA, Rediess S, Shiao S. Tourette syndrome in Monroe County school children. Neurology 1988; 38: 472-475.
12. Carter AS, Pauls DL, Leckman JF, Cohen DJ. A prospective longitudinal study of Gilles de la Tourette syndrome. Journal of the American Academy of Child and Adolescent Psychiatry 1994 ; 33 :377-385.
13. Chappell PB, Leckman JF, Riddle MA. The pharmacologic treatment of tic disorders. En: Lewis M, Riddle M, editors. Child and adolescent psychiatric clinics of North America. Pediatric psychopharmacology. Philadelphia: Saunders; 1995. pp:197-215.
14. Cohen DJ, Ort SI, Leckman JF, Riddle MA, Hardin MT. Familiy functioning and Tourette’s syndrome. En: Cohen DJ, Bruun RD, Leckman JF, editors. Tourette’s syndrome and tic disorders. New York: Wiley; 1988.
15. Comings DE, Comings BG. A controlled study of Tourette syndrome. I. Attention-deficit disorder, learning disorders and related school problems. II. Conduct. American Journal of Human Genetics 1987; 41:701-760.
16. Comings DE, Himes JA, Comings BG. An epidemiological study of Tourette`s syndrome in a single school district. Journal Clinical Psychiatry 1990; 51:463-469.
17. Cook EH, Charak DA, Trapani C, Zelko FAJ, Arida J, Kieffer JE, Jaselskis CA, Leventhal BL. Sertraline treatment of obsessive-compulsive disorder in children and adolescents: Preliminary findings. American Academy of Child and Adolescent Psychiatry Meeting 1994; Abstracts 10(no. NR-71),57.
18. de Veaugh-Geiss J, Moroz G, Biederman J, Cantwell D, Fontaine R, Greist JH, reichler R, Katz R, Landau P. Clomipramine hydrochloride in childhood and adolescent obsessive-compulsive disorder: A multicenter trial. J Am Acad Child Adolesc Psychiat 1992; 31:45-49.
19. Flament MF, Rapoport JL, berg CJ, Sceery W, Kitts C, Mellstrom B, Linnoila M. Clomipramine treatment of childhood obsessive compulsive disorder: A double-blind controlled study. Archives of general Psychiatry 1985; 42:977-983.
20. Hagin RA, Beecher R, pagano G, Kreeger H. Effects of Tourette syndrome on learning. Advances in Neurology 1982;35:323-328.
21. Jagger J, Prusoff B, Cohen DJ, Kidd KK, Carbonari CM, John K. The epidemiology of Tourette’s syndrome: A pilot study. Schizophrenia Bulletin 1982, 8:267-277.
22. Lerer RJ. Motor tics, Tourette syndrome and learning disabilities. Journal of Learning Disabilities 1987; 20:266-267.
23. Lombroso PJ, Scahill I, King RA, et al. Risperidone treatment of children and adolescents with chronic tic disorders: a preliminary report. J Am Acad Child Adolesc Psychiat 1995;34:1147-1152.
24. Organización Mundial de la Salud. Décima revisión de la clasificación internacional de las enfermedades. Trastornos mentales y del comportamiento. Criterios diagnósticos de investigación. Madrid: Meditor; 1994.
25. Pauls DL, Leckman JF, Cohen DJ. Evidence against a relationship between Tourette’s syndrome and anxiety, depression, panic and phobic disorders. British Journal of Psychiatry 1994; 164:215-221.
26. Rapoport JL, Leonard HL, Swedo SE, Lenane MC. Obsessive compulsive disorder in children and adolescents: Issues in management. Journal of Clinical Psychiatry 1993; 54:27-29.
27. Regeur L, Pakkenberg B, Fog R, Pakkenberg H. Clinical features and long-term treatment with pimozide in 65 patients with Gilles de la Tourette’s syndrome. Journal of Neurology, Neurosurgery and Psychiatry 1986; 49:791-795.
28. Riddle MA, Hardin MT, Towbin KE, Leckman JF, Cohen DJ. Tardive dyskinesia following haloperidol treatment for Tourette’s syndrome. Archives of general Psychiatry 1987; 44:98-99.
29. Robertson MM, Yakeley JW. Obsessive-compulsive disorder and selfinjurious behavior. En: Kurlan R, editor. Handbook of Tourette’s syndrome and related tic and behavioural disorders. New York: Marcel Dekker; 1993.
pp:45-87.
30. Scahill L, Lynch KA, Ort SI. Tourette syndrome: Update and review. Journal of School Nursing 1995;11:24-32.
31. Scahill L, Ort SI, Hardin MT. Tourette’s syndrome.Part I: Definition and diagnosis. Archives of Psychiatry Nursing 1993; 7:203-208.
32. Scahill L, Ort SI, Hardin MT. Tourette’s syndrome. Part II: Contemporary approaches to assessment and treatment. Archives of Psychiatry Nursing 1993; 7: 209-216.
33. Scahill L. Contemporary approaches to pharmacotherapy in Tourette’s syndrome and obsessive-compulsive disorder. Journal of child and Adolescent psychiatric Nursing 1996; 9: 27-43.
34. Shady GA, Fulton WA, Champion LM. Tourette syndrome and educational problems in Canada. Neuroscience and Biobehavioral reviews 1988;12:263-265.
35. Shapiro ES, Shapiro AK, Fulop G, Hubbard M, Mandeli J, Nordlie J, Phillips RA. Controlled study of haloperidol, pimozide, and placebo for the treatment of Gilles de la Tourette’s syndrome. Archives of General Psychiatry 1989; 46:722-730.
36. Stein DJ, Bouwer C, Hawkridge S, Emsley RA. Risperidone augmentation of serotonin reuptake inhibitors in obsessive-compulsive and related disorders. J Clin Psychiatry 1997; 58:119-122.
37. Stephens RJ, Bassel C, Sandor P. Olanzapine in the treatment of aggression and tics in children with Tourette’s syndrome: a pilot study. J Child Adolesc Psychopharmacol 2004; 14:255-266.
38. Stokes A, Bawden HN, Camfield PR, Backman JE, Dooley MB. Peer problems in Tourette’s disorder. Pediatrics 1991, 87:936-942.
39. Zahner GEP, Clubb MM, Leckman JF, Pauls DL. The epidemiology of Tourette’s syndrome. En: Cohen DJ, Bruun RD, Leckman JF (eds). Tourette’s Syndrome and Tic Disorders. New York: Wiley; 1988. págs.
2. Azrin NH, Peterson AL. Habit reversal for the treatment of Tpourette syndrome. Behaviour Research and Therapy 1988; 11:347-355.
3. Azrin NH, Peterson AL. Treatment of Tourette syndrome by habit reversal: a waiting-list control group comparison. Behaviour Therapy 1990’; 21:305-318.
4. Bengi Semerci Z. Olanzapine in Tourette’s disorder. J Am Acad Child Adolesc Psychiat 2000; 39:140.
5. Bronheim S. An educator’s guide to Tourette syndrome. Journal of Learning Disabilities 1991; 24:17-22.
6. Bruggeman R, van der Linden C, Buitelaar JK, et al. Risperidone versus pimozide in Tourette’s disorder: a comparative double-blind parallelgroup study.J Clin Psychiatry 2001;50:912-924.
7. Bruun RD, Budman CL. Risperidone as a treatment for Tourette’s syndrome. J Clin Psychiatry 1996;57:29-31.
8. Bruun RD. Subtle and under recognized side effects of neuroleptic treatment in children with Tourette’s disorder. American Journal of Psychiatry 1988; 145:621-624.
9. Bruun RD. The natural history of Tourette’s syndrome. En: Cohen DJ, Bruun RD, Leckman JF, editors. Tourette’s syndrome and tic disorders: clinical understanding and treatment. New York: Wiley; 1988. págs. 21-39.
10. Burd L, Kerbeshian L, Wikenheiser M, Fisher W. A prevalence study of Gilles de la Tourette syndrome in North Dakota school-age children. J Am Acad Child Adolesc Psychiat 1986; 25:552-553.
11. Caine ED, McBride MC, Chiverton P, Bamford KA, Rediess S, Shiao S. Tourette syndrome in Monroe County school children. Neurology 1988; 38: 472-475.
12. Carter AS, Pauls DL, Leckman JF, Cohen DJ. A prospective longitudinal study of Gilles de la Tourette syndrome. Journal of the American Academy of Child and Adolescent Psychiatry 1994 ; 33 :377-385.
13. Chappell PB, Leckman JF, Riddle MA. The pharmacologic treatment of tic disorders. En: Lewis M, Riddle M, editors. Child and adolescent psychiatric clinics of North America. Pediatric psychopharmacology. Philadelphia: Saunders; 1995. pp:197-215.
14. Cohen DJ, Ort SI, Leckman JF, Riddle MA, Hardin MT. Familiy functioning and Tourette’s syndrome. En: Cohen DJ, Bruun RD, Leckman JF, editors. Tourette’s syndrome and tic disorders. New York: Wiley; 1988.
15. Comings DE, Comings BG. A controlled study of Tourette syndrome. I. Attention-deficit disorder, learning disorders and related school problems. II. Conduct. American Journal of Human Genetics 1987; 41:701-760.
16. Comings DE, Himes JA, Comings BG. An epidemiological study of Tourette`s syndrome in a single school district. Journal Clinical Psychiatry 1990; 51:463-469.
17. Cook EH, Charak DA, Trapani C, Zelko FAJ, Arida J, Kieffer JE, Jaselskis CA, Leventhal BL. Sertraline treatment of obsessive-compulsive disorder in children and adolescents: Preliminary findings. American Academy of Child and Adolescent Psychiatry Meeting 1994; Abstracts 10(no. NR-71),57.
18. de Veaugh-Geiss J, Moroz G, Biederman J, Cantwell D, Fontaine R, Greist JH, reichler R, Katz R, Landau P. Clomipramine hydrochloride in childhood and adolescent obsessive-compulsive disorder: A multicenter trial. J Am Acad Child Adolesc Psychiat 1992; 31:45-49.
19. Flament MF, Rapoport JL, berg CJ, Sceery W, Kitts C, Mellstrom B, Linnoila M. Clomipramine treatment of childhood obsessive compulsive disorder: A double-blind controlled study. Archives of general Psychiatry 1985; 42:977-983.
20. Hagin RA, Beecher R, pagano G, Kreeger H. Effects of Tourette syndrome on learning. Advances in Neurology 1982;35:323-328.
21. Jagger J, Prusoff B, Cohen DJ, Kidd KK, Carbonari CM, John K. The epidemiology of Tourette’s syndrome: A pilot study. Schizophrenia Bulletin 1982, 8:267-277.
22. Lerer RJ. Motor tics, Tourette syndrome and learning disabilities. Journal of Learning Disabilities 1987; 20:266-267.
23. Lombroso PJ, Scahill I, King RA, et al. Risperidone treatment of children and adolescents with chronic tic disorders: a preliminary report. J Am Acad Child Adolesc Psychiat 1995;34:1147-1152.
24. Organización Mundial de la Salud. Décima revisión de la clasificación internacional de las enfermedades. Trastornos mentales y del comportamiento. Criterios diagnósticos de investigación. Madrid: Meditor; 1994.
25. Pauls DL, Leckman JF, Cohen DJ. Evidence against a relationship between Tourette’s syndrome and anxiety, depression, panic and phobic disorders. British Journal of Psychiatry 1994; 164:215-221.
26. Rapoport JL, Leonard HL, Swedo SE, Lenane MC. Obsessive compulsive disorder in children and adolescents: Issues in management. Journal of Clinical Psychiatry 1993; 54:27-29.
27. Regeur L, Pakkenberg B, Fog R, Pakkenberg H. Clinical features and long-term treatment with pimozide in 65 patients with Gilles de la Tourette’s syndrome. Journal of Neurology, Neurosurgery and Psychiatry 1986; 49:791-795.
28. Riddle MA, Hardin MT, Towbin KE, Leckman JF, Cohen DJ. Tardive dyskinesia following haloperidol treatment for Tourette’s syndrome. Archives of general Psychiatry 1987; 44:98-99.
29. Robertson MM, Yakeley JW. Obsessive-compulsive disorder and selfinjurious behavior. En: Kurlan R, editor. Handbook of Tourette’s syndrome and related tic and behavioural disorders. New York: Marcel Dekker; 1993.
pp:45-87.
30. Scahill L, Lynch KA, Ort SI. Tourette syndrome: Update and review. Journal of School Nursing 1995;11:24-32.
31. Scahill L, Ort SI, Hardin MT. Tourette’s syndrome.Part I: Definition and diagnosis. Archives of Psychiatry Nursing 1993; 7:203-208.
32. Scahill L, Ort SI, Hardin MT. Tourette’s syndrome. Part II: Contemporary approaches to assessment and treatment. Archives of Psychiatry Nursing 1993; 7: 209-216.
33. Scahill L. Contemporary approaches to pharmacotherapy in Tourette’s syndrome and obsessive-compulsive disorder. Journal of child and Adolescent psychiatric Nursing 1996; 9: 27-43.
34. Shady GA, Fulton WA, Champion LM. Tourette syndrome and educational problems in Canada. Neuroscience and Biobehavioral reviews 1988;12:263-265.
35. Shapiro ES, Shapiro AK, Fulop G, Hubbard M, Mandeli J, Nordlie J, Phillips RA. Controlled study of haloperidol, pimozide, and placebo for the treatment of Gilles de la Tourette’s syndrome. Archives of General Psychiatry 1989; 46:722-730.
36. Stein DJ, Bouwer C, Hawkridge S, Emsley RA. Risperidone augmentation of serotonin reuptake inhibitors in obsessive-compulsive and related disorders. J Clin Psychiatry 1997; 58:119-122.
37. Stephens RJ, Bassel C, Sandor P. Olanzapine in the treatment of aggression and tics in children with Tourette’s syndrome: a pilot study. J Child Adolesc Psychopharmacol 2004; 14:255-266.
38. Stokes A, Bawden HN, Camfield PR, Backman JE, Dooley MB. Peer problems in Tourette’s disorder. Pediatrics 1991, 87:936-942.
39. Zahner GEP, Clubb MM, Leckman JF, Pauls DL. The epidemiology of Tourette’s syndrome. En: Cohen DJ, Bruun RD, Leckman JF (eds). Tourette’s Syndrome and Tic Disorders. New York: Wiley; 1988. págs.
© 2021 AEPNyA Todos los derechos reservados
