Selective serotonine recaptative inhibitors. Side effects in children and adolescents
Downloads
Published
How to Cite
Issue
Section
Keywords:
Selective serotonin reuptake inhibitors, triciclyc antidepressants, psychopharmacology, side effectsAbstract
The advent of the selective recaptative inhibitors (SSR/s) has been a major advance in psychiatry as it seems that they do have fewer side effects, lower toxicity in overdose and a potentially broader range of clinical indications, The goal of this article is to review the safety and side effects of the use of SSR/s in children and adolescents. The conclusions are that as in adults, also in children and adolescents SSR/s are potentially useful in treating a variety of psychiatric disorders, specially anxiety disorders, depressive disorders and obsessive-compulsive disorder. Available data suggest that the safety of these medications is good in the short time, but further research is essential to provide the necessary information on the efficacy, safety on the long time, and pharmacokinetics.
Downloads
References
Velasco-Martín A: Introducción a la psicofarmacología del niño y del adolescente. En Mardomingo MJ, Rodríguez-Ramos P, Velasco-Martín A: Psicofarmacología del niño y del adolescente. Madrid, Díaz de Santos, 1 997, 1-44.
Brown TM, Soudemire A: Psychiauic side effecls of prescription and over the counter medications. American Psychiatric Press, Washington DC, 1998.
Mardomingo MJ, Rodríguez-Ramos P, Velasco A: Psicofarmacología del niño y del adolescente. Madrid, Díaz de santos, 1997.
Toro J, Castro J, García M, Lázaro L: Psicofa,macología de la infancia y adolescencia. Barcelona, Masson, 1998.
M ardomingo MJ: Paulas generales del tratamiento con psicofármacos En Mardomingo MJ, Rodríguez-Ramos P, Yelasco-Marlín A: Psicofarmacología del niño y del adolescente. Madrid, Díaz de Santos, 1997, 45-50.
Mardomingo MJ: Antidepresivos. En Mardomingo MJ, RodríguezRamos P, Velasco-Martín A: Psicofam1acología del niño y del adolescente. Madrid, Díaz de Santos, 1997, 101-140.
Davis DM: Textbook of adverse drug reactions. 4th Edition, Oxford University Press, Oxford 1991.
Branconnier RJ, Cole JO, Ghazvinian S: Clinical pharmacology of bupropion and imipramine in elderly depressives. J Clin Psychiatry. 1983; 44: 130-133.
Dunbar GC, Cohn JB, Feighner JP, et al: A comparison of paroxetine, imipramine and placebo in depressed outpatients. Br J Psychiatry. 1991; 159:394-398. https://doi.org/10.1192/bjp.159.3.394
Preskorn SH: Comparison of the tolerability of bupropion, fluoxetine, imipramine, nefazodone, paroxetine, sertraline, and venlafaxine. J Clin Psychiatry. 1995; 56 (suppl 6): 12-21.
Song F. Freemantle N, Sheldon TA el al., Selective serotonin reuptake inhibitors: meta-analysis of efficacy and acceptability. Br Med J. 1993; 306:683-687. https://doi.org/10.1136/bmj.306.6879.683
Geller B, Fox LW, Fletcher M. Effecl of Lricyclic antidepressants on switching to mania on the onset of bipolarily in depressed 6- to 12-yearsolds. J Am Acad Child Adolesc Psychiatry. 1993; 32 (1 ):43-50. https://doi.org/10.1097/00004583-199301000-00007
Preskorn SH, Weller E, Jerkovich G, et al. Depression in children: concentration dependen! CNS toxicity of tricyclic antidepressants. Psychopharmacol Bull. 1988; 24:275-279.
Wilens T, BiedermanJ, Baldessarini J, el al. The cardiovascular effects of tricyclic antidepressants in children and adolescents. J Am Acad Child Adolesc Psychiatry. 1996; 35:1491-1501. https://doi.org/10.1097/00004583-199611000-00018
Leonard HL, Swedo SE, Rapopo1t JL et al. Trealment of obsessive compulsive disorder with clomipramine and desiprarnine in children and adolescents: a double-blind crossover comparison. Arch Gen Psychiatry. 1989; 46:1088-I092. https://doi.org/10.1001/archpsyc.1989.01810120030006
Binnaher B. Watennan GS, Ryan N et al. Fluoxetine for childhood anxiety disorders. J Am Acad Child Adolesc Psychiatry. 1994; 33:993-999. https://doi.org/10.1097/00004583-199409000-00009
Riddle MA, Scahill L King RA el al, Double-blind, crossover tria! Of fluoxetine and placebo in children and adolescents wilh obsessive-cornpulsive disorder. J Am Acad Child Adolesc Psychiatry. 1992; 31: 1062-1060. https://doi.org/10.1097/00004583-199211000-00011
Rodríguez-Ramos P. de Dios JL, San Sebastián J, Sordo L, Mardomingo MJ. E. Effects of paroxetine in depressed adolescents. European Journal of Clinical Research. 1996; 8:49-61.
Rey-Sánchez F, Gutiérrez-Casares JR. Paroxetine in children with major depressive disorder: an open tria!. J Am Acad Child Adolesc. Psychiatry. 1997; 36:1443-1447. https://doi.org/10.1097/00004583-199710000-00027
March JS el al. Sertraline in children and adolescents with obsessivecompulsive disorder. A multicenter randomized controlled tria]. JAMA. 1998; 280: 1752-1785. https://doi.org/10.1001/jama.280.20.1752
Alderrnan J, Wolkow R, Chung M, Johnston H. Sertraline treatment of children and adolescents with obsessive-compulsive disorder or depression: pharmacokinetics, tolerability, and Efficacy. J Am Acad Child Adolesc. Psychiatry. 1998; 37:386-394. https://doi.org/10.1097/00004583-199804000-00016
Rodríguez-Ramos P, Mardomingo MJ: Respuesta a la sertralina en adolescentes con trastorno obsesivo-compulsivo. Actas Luso-Esp Neurol Psiquiat. 1998; 26, 17-21.
Rodríguez-Ramos P, Mardomingo MJ: Obsessive adolescents with sertraline growing-up: A 3-5 year follow-up (remitido para publicación).
Mandok M, Tapia MR, Tapia MA, Surnmer G, Parker J; Venlafaxine in the treatment of children and adolescents with major depression. Psychopharmacology Bulletin. 1997; 33 (!), 149-154.
Emslie GJ, Rush AJ, Weinberg WA, Kowatch RA, Hughes CW. Carrnody T, Reintelmann J: A double-blind, randornized, placebo-controlled trial of fluoxeline in children and adolescents with depression. Arch Gen Psychiatry. 1997; 54:1031-1037. https://doi.org/10.1001/archpsyc.1997.01830230069010
© 2021 AEPNyA Todos los derechos reservados
