Can a bacteria require psychotherapy?
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Copyright (c) 2025 Revista de Psiquiatría Infanto-Juvenil

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DOI:
https://doi.org/10.31766/revpsij.v42n3a3Keywords:
tics, autoimmune diseases, obsessive-compulsive disorder, streptococcal infections, paediatricsAbstract
Introduction: Neuropsychiatric symptoms in childhood pose a significant clinical challenge due to their emotional impact on families and the complexity of their diagnosis. Tics are particularly challenging because of their frequency and the wide range of potential underlying causes that must be considered. Among these, Paediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections (PANDAS) remain a controversial entity, with diagnostic criteria still under review and no definitive consensus. Case report: This article presents the case of a child who experiences a sudden worsening of tic and associated neuropsychiatric symptoms, along with the most relevant clinical data supporting the diagnosis. Discussion and conclusion: This clinical case provides further evidence as to the potential existence of PANDAS as a differential diagnosis, highlighting the need for continued investigation into its mechanisms, validity and management in clinical practice.
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González Campillo T, López Laso E, Madruga Garrido M. Tics. Protoc diagn ter pediatr. 2022;1: 295-303. https://www.aeped.es/sites/default/files/documentos/29_0.pdf
Allen AJ, Leonard HL, Swedo SE. Case Study: A New Infection-Triggered, Autoimmune Subtype of Pediatric OCD and Tourette’s Syndrome. J Am Acad Child Adolesc Psychiatry. 1995;34(3): 307-11. https://doi.org/10.1097/00004583-199503000-00015
Swedo SE, Leonard HL, Garvey M, Mittleman B, Allen AJ, Perlmutter S, Dow S, Zamkoff J, Dubbert BK, Lougee L. Pediatric Autoimmune Neuropsychiatric Disorders Associated With Streptococcal Infections: Clinical Description of the First 50 Cases. Am J Psychiatry. 1998;155(2): 264-71. https://doi.org/10.1176/ajp.155.2.264
Esposito S, Bianchini S, Baggi E, Fattizzo M, Rigante D. Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections: an overview. Eur J Clin Microbiol Infect Dis. 2014;33: 2105-9. https://doi.org/10.1007/s10096-014-2185-9
Huey ED, Zahn R, Krueger F, Moll J, Kapogiannis D, Wassermann EM, Grafman J. A psychological and neuroanatomical model of obsessive-compulsive disorder. J Neuropsychiatry Clin Neurosci. 2008;20(4): 390-408. https://doi.org/10.1176/jnp.2008.20.4.390
Swedo ES. From Research Subgroup to Clinical Syndrome: Modifying the PANDAS Criteria to Describe PANS (Pediatric Acute-onset Neuropsychiatric Syndrome). Pediatr Ther. 2012;2(2): 1000113. https://doi.org/10.4172/2161-0665.1000113
Singer HS, Gilbert DL, Wolf DS, Mink JW, Kurlan R. Moving from PANDAS to CANS. J Pediatr. 2012;160(5): 725-31. https://doi.org/10.1016/j.jpeds.2011.11.040
LaRusso MD, Abadia CE. Symptom flares after COVID-19 infection versus vaccination among youth with PANS/PANDAS. Allergy Asthma Proc. 2023;44(5): 361-67. https://doi.org/10.2500/aap.2023.44.230049
Xie O, Davies MR, Tong SYC. Streptococcus dysgalactiae subsp. equisimilis infection and its intersection with Streptococcus pyogenes. Forrest GN, editor. Clin Microbiol Rev. 2024;37(3): e00175-23. https://doi.org/10.1128/cmr.00175-23
Marazziti D, Palermo S, Arone A, Massa L, Parra E, Simoncini M, Martucci L, Beatino MF, Pozza A. Obsessive-Compulsive Disorder, PANDAS, and Tourette Syndrome: Immuno-inflammatory Disorders. En: Kim Y-K, editor. Neuroinflammation Gut-Brain Axis Immun Neuropsychiatr Disord. Singapore: Springer Nature Singapore; 2023. p. 275-300. https://link.springer.com/10.1007/978-981-19-7376-5_13