Aripiprazol en el autismo: seguridad y tolerancia
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Aripiprazol, tratamiento, niños, trastorno autistaResumen
El objetivo de este estudio es hacer una revisión sobre la eficacia y seguridad de aripiprazol en el tratamiento de los síntomas de irritabilidad asociados al trastorno autista. También se revisa la mejoría en otros síntomas de la escala Aberrant Behavior Checklist (ABC). Para ello hemos revisado tres estudios. Dos son aleatorizados, doble ciego y multicéntricos, 8 semanas de duración, que evaluaban la eficacia de aripiprazol a dosis fijas (5mg/d, 10mg/d, 15mg/d) y a dosis flexibles (2-15mg/d) comparados con placebo. El tercer estudio fue un análisis post hoc de los dos anteriores y evaluó el efecto del aripiprazol en los 58 ítems de la escala ABC. Los resultados fueron significativos con aripiprazol en comparación con placebo en los siguientes ítems de la escala ABC y con todas las dosis de aripiprazol usadas: cambios rápidos de humor, gritos, patadas, movimientos repetitivos, bullicioso, constantemente corre o salta y tiende a ser excesivamente activos. Con la dosis de 15 mg /d se obtuvieron resultados significativos en un mayor número de items.
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