Lisdexanfetamina en niños y adolescentes con trastorno por déficit de atención e hiperactividad (TDAH): una revisión sistemática global
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Palabras clave

lisdexanfetamina
niños
adolescentes
TDAH
farmacocinética
farmacodinámica
seguridad
tolerabilidad
eficacia

Cómo citar

Herreros, Óscar, Díaz Atienza, F., Gastaminza, X., Monzón, J., Rubio, B., & Muñoz, A. (2015). Lisdexanfetamina en niños y adolescentes con trastorno por déficit de atención e hiperactividad (TDAH): una revisión sistemática global. Revista De Psiquiatría Infanto-Juvenil, 32(1), 7-30. Recuperado a partir de http://aepnya.eu/index.php/revistaaepnya/article/view/111

Resumen

El Trastorno por Déficit de Atención e Hiperactividad (TDAH) es uno de los trastornos más frecuentes en Psiquiatría Infanto-Juvenil, y muy habitualmente requiere tratamiento farmacológico dentro de su plan terapéutico. Dentro de estos, desde hace cerca de un año se dispone en España de la lisdexanfetamina, novedoso tanto por ser una anfetamina como por ser un profármaco.

Objetivo: revisar y resumir la evidencia existente sobre lisdexanfetamina y su uso en niños y adolescentes afectos de TDAH.

Método: búsqueda bibliográfica exhaustiva en PubMed con los siguientes términos: lisdexamfetamine, OR lisdexamphetamine, OR lisdexanfetamina.

Resultados: la lisdexanfetamina es un profármaco seguro, con un perfil de efectos adversos similar al de los otros tratamientos farmacológicos del TDAH conocidos, y muy eficaz para su tratamiento en niños y adolescentes, con un bajo potencial de abuso y uso inadecuado, y una respuesta clínica estable y prolongada a lo largo del día.

Limitaciones: Aunque es un fármaco con eficacia y seguridad conocida en sus casi 9 años de comercialización en EEUU y su principio activo fue uno de los primeros en usarse para el tratamiento del TDAH, precisa llevar a cabo estudios prospectivos con horizontes temporales más amplios que los actuales, que contemplen seguridad y eficacia a largo plazo, eficacia frente a otros tratamientos en TDAH, y su uso en el paciente real.

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Referencias

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